Sodium-glucose cotransporter-2 inhibition and the insulin: Glucagon ratio: Unexplored dimensions
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چکیده
منابع مشابه
Sodium-Glucose Cotransporter-2 Inhibition and the Glomerulus: A Review
UNLABELLED Blood glucose-lowering treatment options generally target insulin action or beta-cell function. In diabetes, expression of the sodium-glucose cotransporter-2 (SGLT2) genes is up-regulated and renal threshold increased, resulting in increased glucose reabsorption from glomerular filtrate, reducing urinary glucose excretion and worsening the hyperglycemic condition. The SGLT2 inhibitor...
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OBJECTIVE Sodium-glucose cotransporter 2 (SGLT2) inhibitors cause substantially less weight loss than expected from the energy excreted via glycosuria. Our aim was to analyze this phenomenon quantitatively. RESEARCH DESIGN AND METHODS Eighty-six patients with type 2 diabetes (HbA1c 7.8 ± 0.8% [62 ± 9 mmol/mol], estimated glomerular filtration rate [eGFR] 89 ± 19 mL ⋅ min(-1) ⋅ 1.73 m(-2)) rec...
متن کاملEnergy Balance After Sodium Glucose Cotransporter 2 (SGLT2) Inhibition
Eighty-six patients with type 2 diabetes (HbA1c = 7.86 0.8% [62 6 9 mmol/mol], estimated glomerular filtration rate [eGFR] = 89 6 19 mL · min · 1.73 m) received empagliflozin (25 mg/day) for 90 weeks with frequent (n = 11) assessments of body weight, eGFR, and fasting plasma glucose (FPG). Time-dependent glucose filtration was calculated as the product of eGFR and FPG; time-dependent glycosuria...
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Diabetic nephropathy is the most common cause of end-stage renal disease requiring chronic dialysis or renal transplantation, resulting in high morbidity, mortality and societal costs to Canadians. Unfortunately, glycemic targets are often not achieved, and existing medications that block the renin-angiotensin-aldosterone system only offer partial protection against the development of renal and...
متن کاملRenal Sodium - Glucose Cotransporter Inhibition in the Management of Type 2 Diabetes 2 Mellitus 3
Revised 8-19-2015 (LOA) 1 Renal Sodium-Glucose Cotransporter Inhibition in the Management of Type 2 Diabetes 2 Mellitus 3 Muhammad A Abdul-Ghani, MD, PhD, Luke Norton, Ph.D., and Ralph A DeFronzo, MD 4 Division of Diabetes, University of Texas Health Science Center at San Antonio, Texas, USA 5 6
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ژورنال
عنوان ژورنال: Indian Journal of Endocrinology and Metabolism
سال: 2015
ISSN: 2230-8210
DOI: 10.4103/2230-8210.152793